Alan
I understand exactly what you mean..
Even if I really wanted ,say, a Gibson SG, the overall 'feel' of the guitar just wouldn't suit me and I wouldn't feel comfortable playing it.
However, with a Strat type guitar, or almost any Fender solidbody, they just feel 'right' to me..I've been spoiled by Leo I think!
Thinking about it, maybe it has something to do with the differing body and neck designs, and how the necks are fitted to the body, and how odd it feels to me for virtually the whole of the fingerboard and neck being located right on the edge of the body..
Then there's pickups...however much I try to appreciate them, I can't really get on with humbucking pickups...I prefer virtually any kind of single coils.
I also prefer single sided headstocks too..